DDI White

 

Key Advantages

  • Assessment of phase I and phase II detoxification
  • Assessment of toxin exposure and impaired liver function
  • No hepatotoxic challenge drugs required
  • Simple first morning void urine collection

 

Introduction

The body continually attempts to eliminate chemical toxins through enzymatic processes in the liver. Urinary D-glucaric acid, a by-product of phase I detoxification, is a valuable indicator of chemical exposure or liver damage. Urinary mercapturic acids are direct end product metabolites of conjugated xenobiotics. Combined assessment of the urinary levels of the two analytes provides valuable information about exposure to xenobiotics and liver disease, and the capability of the liver to eliminate toxins.

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