- H. Pylori infection represents up to 20% lifetime chance of peptic ulcers and 2% chance of Gastric Cancer
- Stool antigen over 95% sensitive and 94% specific for detecting H. Pylori infection (unlike that of serum antibody which has poor sensitivity)
The awareness of Helicobacter pylori in gastrointestinal diseases has increased greatly since Marshall and Warren described the presence of
Campylobacter-like organisms in the antral mucosa of patients with histological evidence of antrum gastritis and peptic ulcers, especially duodenal ulcers. The strong correlation between the presence of H. pylori and histologically confirmed gastritis, peptic ulcer disease and gastric carcinoma, as well as disease resolution after H. pylori eradication, indicates a causative relationship.