SEX HORMONE BINDING GLOBULIN (SHBG) CLINICAL PEARLS (EVEN THOUGH WE DON’T TEST IT)

Commonly when we talk with all of you smart clinicians, you have done additional work-up besides our DUTCH testing. Many will run thyroid panels, CBC, metabolic panels, food testing, stool testing, etc. and we are asked about SHBG.

SHBG is a glycoprotein binding globulin made primarily in the liver that requires calcium and zinc to form. Its job is to preferentially bind up DHT, testosterone, androstenediol (not androstenedione), estradiol, and then estrone in that order. DHEA, but not DHEA-s, can bind weakly to SHBG.

Progesterone and cortisol bind to transcortin (AKA Cortisol Binding Globulin – CBG).

SHBG is degraded in the extra-cellular space therefore it does not come through the urine as the fully formed glycoprotein, but degraded into piece and parts by your immune system. As a result, it is not tested in the DUTCH testing.

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ABOUT THE AUTHOR:

Dr Carrie Jones, ND, MPH, Medical Director for Precision Analytical

Dr. Carrie Jones’ passion and expertise lies in the areas of hormonal, adrenal, and thyroid health. She recognises that imbalance can occur at any age and believes it is important to look at the big picture such as the appropriate use of lab testing. Dr. Jones graduated from the National University of Natural Medicine (NUNM) in Portland, Oregon then went on to complete her residency in women’s health, endocrinology and hormones. Later she graduated from Grand Canyon University’s Master of Public Health program with a goal of doing more international work and health empowerment. Dr. Jones is an adjunct professor at NUNM and regularly consults, lectures, and writes on the topic of hormones, thyroid, adrenals, autoimmune and more.

As the Medical Director for Precision Analytical, Inc., her goals are to provide ongoing cutting edge integrative clinical education to the large network of providers paving the way of healthcare with functional medicine.